Description

4-Chloromethcathinone

(also known as 4-CMC and clephedrone ) is a stimulant drug of the cathinone class that has been sold online as a designer drug.4-CMC produces similar effects to mephedrone, and has been sold as an alternative in countries where mephedrone was scheduled

4-CMC produces similar side effects to mephedrone , including: increased blood pressure, tachycardia, hyperthermia, and anxiety Effects

Frozen hash

Neurotoxicity

Its chemical structure closely resembles para-chloromethamphetamine, raising concerns about its potential to readily
induce cell death of serotoninergic neurons. However, no neurotoxicity of this kind has been found to occur, but studies
involving mice do indicate that it is neurotoxic through other mechanisms, similarly to other cathinone’s. 4-CMC is
cytotoxic and induces oxidative stress, more so than 4MMC.

Pharmacology
Similar to mephedrone, 4-CMC mainly acts as a serotonin–norepinephrine–dopamine releasing agent (SNDRA), and partially
as a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) with similar potency.

Pharmacodynamics

Similar to mephedrone, 4CMC mainly acts as a serotonin–norepinephrine–dopamine releasing agent (SNDRA), and partially as
a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) with similar potency.

Legality
As of October 2015, 4CMC is a controlled substance in China.

4CMC is considered a Schedule 1 substance in Virginia.

In December 2019, the UNODC announced scheduling recommendations placing 4CMC into Schedule II.

See also
Chloromethcathinone
Methylmethcathinone
Bromomethcathinone
Chloroamphetamine
Cl-3-MMC
Cl-PVP
Ethylmethcathinone
Methylmethcathinone
Substituted cathinone